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Pharmacological action and application of hesperidin

1. Bacteria, anti-inflammatory and anti-virus

Intraperitoneal injection of hesperidin 175~250 mg/kg in mice has the effect of antagonizing ventrotoxin or lysolecithin and increasing vascular permeability: intraperitoneal injection of 10 mg/kg can only affect the inflammatory response of rat croton oily granuloma cyst It has an inhibitory effect and significantly reduces the exudate in the capsule. Hesperidin has a vitamin P-like effect, can reduce capillary permeability, prevent microtubule bleeding, antagonize the increase in vascular permeability caused by histamine and lysolecithin, and stop subcutaneous hemorrhage in mice caused by viper venom. Hesperidin has a broad-spectrum antibacterial effect on food contamination when the mass percentage is 0.06% to 0.9% and the pH is 5-9. Hesperidin still has the same antibacterial effect after heat treatment. Before adding the vesicular oral virus, the mouse fiber cells are pre-incubated in 200 mg/mL hesperidin. After this treatment, the Hela cells are pre-treated with this product to prevent influenza virus infection. The antiviral activity of this product Can be eliminated by hyaluronidase.

2. Prevent cardiovascular diseases

Hesperidin has the functions of maintaining normal osmotic pressure of blood vessels, reducing blood vessel fragility, shortening bleeding time, lowering blood lipids and preventing and treating atherosclerosis. Hesperidin can prolong the survival time of rats fed with thromboembolism and atherosclerosis diets respectively. It can be used as an adjuvant therapy for cardiovascular diseases in clinic, and it is one of the main raw materials for the medicine Mai Neng. Hesperidin can reduce plasma malondialdehyde content, prevent LDL oxidation, reduce fibroblast damage by eliminating intracellular peroxynitrite, prevent degenerative diseases of heart and brain nerve cells, and effectively prevent arteriosclerosis.

3. Effect on gastrointestinal function and smooth muscle

Hesperidin has an excitatory effect on the gastrointestinal tract, and obviously antagonizes the intestinal gastric emptying and small intestinal propulsion inhibitory effects caused by atropine and epinephrine. It has no effect on gastric emptying and acceleration of small intestine advancement caused by the new stage of Ming Ming. The effect on smooth muscle is first temporarily excited, and then inhibited. It is one of the main components of stomach-invigorating and digestive drugs.

4. Enhance the role of vitamin C

Hesperidin can promote the growth rate of guinea pigs, thereby increasing the content of ascorbic acid in the adrenal glands, spleen and white blood cells, improving the aggregation of red blood cells in the blood vessels of the eyeball and conjunctiva and reducing the resistance of capillaries and other diseases caused by vitamin C deficiency.

5. Anti-oxidation of hydroxyl radicals

Cortin has the effect of anti-lipid peroxidation and scavenging hydroxyl free radicals. It is dose-dependent; it also has a significant inhibitory effect on erythrocyte membrane peroxidation caused by hydroxyl free radicals, and it is related to the phenolic hydroxyl in its molecule. Hesperidin has a certain protective effect on the oxidative damage of red blood cell membrane caused by hydroxyl free radicals. Free radicals can accelerate the body's aging, cause cardiovascular diseases, and cause damage to the body at all levels. Studies have shown that hesperidin can scavenge free radicals and improve the body's immunity; it can chelate metal ions and inhibit the generation of free radical initiators, thereby directly scavenge free radicals.

6. Effects on the central nervous system

Hesperidin is a newly discovered flavonoid compound that acts on the central nervous system. It has sedative and hypnotic effects. Orange peel water extract contains hesperidin. It has the effect of significantly inhibiting the central nervous system, and can significantly speed up the falling asleep time of mice given the upper threshold dose of sodium pentobarbital, prolong the sleep time and improve the quality of sleep.

6. Lower cholesterol

Hesperidin can inhibit the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol-O-acyltransferase, reduce the lipids required for apolipoprotein synthesis, and inhibit the activity of microsomal glyceryl transporters , Thereby reducing cholesterol in the liver.

7. Treat rheumatism

Hesperidin has a therapeutic effect on secondary arthritis in adjuvant arthritis rats. It is related to regulating the body's immune function and maintaining the balance of cell network function, and has reference significance for the treatment of human rheumatoid arthritis.

8. Inhibit skin pigmentation and whitening effect

Hesperidin reduces the number of dopa-positive melanocytes and melanocytes, and inhibits UVB-induced pigmentation. The dihydroflavonoid glycosides in citrus fruits have anti-tyrosinase and absorb UV-A, UV-B and SOD-like effects, so as to achieve the effect of skin whitening.

9. Prevent osteoporosis

Lack of estrogen can lead to osteoporosis. Estrogen receptors exist in osteoblasts and bone marrow stromal cells. Hesperidin has a strong affinity for estrogen receptors. It can act on estrogen receptors to effectively prevent bone loss and significantly reduce the number of osteoclasts in the distal femur. .

10. Anti-cancer function

Hesperidin has a significant inhibitory effect on human lung cancer, rectal cancer, kidney cancer, and human breast cancer cells. It is not only non-mutagenic, but also can antagonize the mutagenicity of other chemotherapeutic drugs. It can be used for cancer prevention and is very likely to become one. It is a good raw material for cancer treatment or synthetic medicine.

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