Hesperidin has the functions of maintaining osmotic pressure, enhancing capillary toughness, shortening bleeding time, and lowering cholesterol. It is clinically used in the adjuvant treatment of cardiovascular diseases. It can cultivate a variety of drugs to prevent arteriosclerosis and myocardial infarction. It is a patent medicine. One of the main raw materials of "Mai Tong". It can be used as a natural antioxidant in the food industry. It can also be used in the cosmetics industry.
Hesperidin is mostly found in the waste of citrus processing. If the peel and fruit sac, the content of hesperidin in the mature peel and tissue is the highest (30%-50% of the endocarp, orange network, stone, pulp In 30%-50%, exocarp 10%-20%), juice and orange sac have a lower content of 1%-5%. The extraction methods of hesperidin include solvent extraction, alkali extraction and acid precipitation, carbon powder adsorption, and ion exchange. Among them, the alkali extraction and acid precipitation method is simple in operation, low in cost, and has a high extraction rate.
Orange peel is soluble in dilute alkali and pyridine and hot water above 70℃, slightly soluble in methanol, and almost insoluble in acetone, benzene and chloroform. The extraction of hesperidin mainly uses the two phenolic hydroxyl groups contained in it to react with sodium ions in the solution under alkaline conditions to form sodium salt and dissolve it, and then acidify and cool to make it precipitate out of the solution. The extraction of hesperidin from citrus peel generally adopts hot extraction method and soaking extraction method, and the yield is not ideal.
In recent years, ultrasonic extraction of active ingredients from natural plants (especially Chinese herbal medicines) has been extensively carried out, and certain progress has been made. Use hesperidin for extraction under alkaline conditions by ring-opening dissolution, and separation under acidic conditions by closed-loop precipitation. Increasing the amount of alkali during extraction can reduce the amount of ethanol, but the alkalinity should not be too large, otherwise, hesperidin is easy to be oxidized destroy.
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